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Physik-Institut Group of Laura Baudis

Imaging of radiation-induced color centers with the new benchtop mesoSPIM

We proudly announce our contribution to the publication of "Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples" in Nature Communications  15, 2679 (2024).

This paper introduces the next-generation mesoSPIM (“Benchtop”) microscope, which features increased field of view, improved resolution, higher throughput, portability and lower cost compared to its predecessors. Designed to serve diverse applications in neuroscience and biology, this version includes specific optimizations for particle physics applications,  an outcome of our collaboration with mesoSPIM developers in the context of the PALEOCCENE project. Additionally, the paper showcases our work on imaging of color centers induced by irradiation in transparent crystals, marking the first imaging of color centers within  crystals using light-sheet microscopy. Looking ahead, our group is eager to continue collaborating with the mesoSPIM open-source initiative. We aim to contribute not only to the setup's design for particle detection purposes but also to develop software for data processing and identification of particle-induced signals in mesoSPIM's extensive image datasets.